| Health / Medical Topics |
O-Chloroacetylcarbamoylfumagillol
Definition 1
A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds to and irreversibly inactivates methionine aminopeptidase-2 (MetAP2), resulting in endothelial cell cycle arrest late in the G1 phase and inhibition of tumor angiogenesis. This agent may also induce the p53 pathway, thereby stimulating the production of cyclin-dependent kinase inhibitor p21 and inhibiting angiogenesis. (NCI Thesaurus)
Definition 2
A substance being studied in the treatment of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent. (NCI Dictionary)
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