Oltipraz

Pronunciation

Definition 1

A drug used in cancer prevention. (NCI Dictionary)

Definition 2

A synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types. (NCI Thesaurus)

YOU MAY ALSO LIKE

Olsenella uli

A species of anaerobic, Gram-positive, rod shaped bacteria assigned to the phylum Actinobacteria. This species is non-spore forming, catalase and indole negative,…

Olsenella

A genus of anaerobic, Gram positive, rod shaped bacterium assigned to the phylum Actinobacteria and the family Coriobacteriaceae.

Olsalazine Sodium

The sodium salt form of olsalazine with anti-inflammatory activity. Olsalazine sodium is bioconverted to 5-aminosalicylic acid (5-ASA) in the colon by colonic…

Olsalazine

A prodrug of mesalamine (5-Aminosalicylic acid; 5-ASA) with anti-inflammatory activity. Unabsorbed olsalazine passes through gastrointestinal tract and is cleaved by azoreductases, produced…

Olopatadine Hydrochloride

The hydrochloride salt form of olopatadine, a dual action selective histamine H1 receptor antagonist and mast cell stabilizer with anti-allergic activity. Olopatadine…

Olopatadine

A dual action selective histamine H1 receptor antagonist and mast cell stabilizer with anti-allergic activity. Olopatadine stabilizes mast cells and prevents histamine…