| Health / Medical Topics |
Oncogene DBL
Human oncogene DBL is a mutated form of the MCF.2 cell line derived transforming sequence (MCF2) gene, located at Xq27, which encodes 4 alternative variants of the proto-oncogene DBL protein. Activation of the DBL oncogene is generated by 5-prime recombination with chromosome 3pter-p21 and by 3-prime recombination with chromosome 16p13-q22. (NCI Thesaurus)
YOU MAY ALSO LIKE
Human colony stimulating factor 1 receptor (CSF1R) gene, located at 5q33.2-q33.3, encodes macrophage colony stimulating factor I receptor protein. Mutations in this…
A transforming gene activated in certain human B lymphoid tumors, B-lym was originally detected by transfection of NIH 3T3 cells with DNA…
Human transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A) gene, located at 6p24, encodes transcription factor AP-2 alpha. This…
Any DNA sequence alteration process occurring in a proto-oncogene, resulting in loss of regulation of the gene product, and predisposing the cell…
Human v-abl Abelson murine leukemia viral oncogene homolog 1 (ABL1) gene, located at 9q34.1, encodes proto-oncogene tyrosine-protein kinase ABL1 protein. Alternative splicing…
A gene that is a mutated (changed) form of a gene involved in normal cell growth. Oncogenes may cause the growth of…
