Health / Medical Topics |
Oncogene FPS-FES
Human Oncogene FPS-FES is a mutated variant of FES Gene (FES/FPS Subfamily), which encodes 822 aa 93-kDa Tyrosine-Protein Kinase FES/FPS, a tyrosine-specific protein kinase involved in normal hematopoiesis and containing an FCH and SH2 domain. The FES chromosomal location is linked to a translocation identified in patients with acute promyelocytic leukemia. A truncated transcript is generated utilizing a start site in a far downstream exon. Oncogene FPS-FES disrupts normal cell function. (NCI Thesaurus)
YOU MAY ALSO LIKE
Retrovirus-associated DNA sequences (fos) originally isolated from the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses. The proto-oncogene c-fos encodes a nuclear…
Human Oncogene FGR is a mutated variant of FGR Gene (SRC Family), which encodes 529-aa 60-kDa p55-FGR, a protein tyrosine kinase that…
Oncogene ETS was originally discovered as a chimeric component, along with a truncated v-myb gene, in the genome of E26, an avian…
Human Oncogene ErbB2 is a mutated variant of ERBB2 Gene, which encodes ERRB2 Receptor Protein Tyrosine Kinase, a 185-kDa type I membrane…
ERBB DNA sequences are related to certain avian erythroblastosis virus sequences. The cellular genes encode members of the epidermal growth factor receptor…
Two ERBA proto-oncogenes located on separate chromosomes, encode ERBA alpha and ERBA beta, which are thyroid hormone receptors in the nucleus and…