| Health / Medical Topics |
Oncogenic Osteomalacia
A paraneoplastic disorder affecting the skeletal system. It associated with one of four tumor types: phosphaturic mesenchymal tumor, mixed connective tissue type; osteoblastoma-like tumor; ossifying fibroma-like tumor or non-ossifying fibroma-like tumor. These neoplasms secrete fibroblast growth factor 23, which in addition to causing decreased renal phosphate reabsorption also affects the expression of 25-hydroxy-1-alpha-hydroxylase resulting in poor bone mineralization. Clinical signs include fractures, bone pain and muscle weakness. Once lesions are detected, prognosis is extremely favorable as resection most often results in cure. (NCI Thesaurus)
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