Oncostatin M

Definition 1

A member of the cytokine family that regulates the proliferation and differentiation of a variety of cell types. This family of proteins adopts a four-helix bundle fold with up-up-down-down topology and contains intramolecular disulfide bonds. (DCB-CB, OMIM 165095, and NCI) (NCI Thesaurus)

Definition 2

Oncostatin M, a glycoprotein with an approximate molecular weight of 28,000, was originally isolated from a conditioned medium of human leukemia cells that had been induced to differentiate into macrophage-like cells by treatment with phorbol 12-myristate 13-acetate. OSM has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts; hence, its name. It is a member of the IL-6 family of cytokines that is primarily known for its effects on cell growth. (NCI Thesaurus)

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