Oral Picoplatin

An oral preparation of picoplatin, a third generation platinum compound with antineoplastic activity. Designed to overcome platinum drug resistance, picoplatin alkylates DNA, forming both inter- and intra-strand cross-linkages, resulting in inhibition of DNA replication and RNA transcription and the induction of apoptosis. Because of the increase in steric bulk around the platinum center, there is a relative reduction in the inactivation of picoplatin by thiol-containing species such as glutathione and metallothionein in comparison to cisplatin. (NCI Thesaurus)

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The branch of pathology focusing on diseases and disorders of the oral cavity.

Oral Paste Dosage Form

A paste intended for administration through the mouth.

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Painful sensation in the mouth, tongue, or lips.

Oral Ointment Dosage Form

An ointment intended for administration through the mouth.

Oral Neoplasm

A benign or malignant neoplasm involving the oral cavity and/or the lips.