Library / English Dictionary

ORNITHINE

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

An amino acid that does not occur in proteins but is important in the formation of urea

Classified under:

Nouns denoting substances

Hypernyms ("ornithine" is a kind of...):

amino acid; aminoalkanoic acid (organic compounds containing an amino group and a carboxylic acid group)

Credits

 Context examples: 

This gene plays a role in ornithine metabolism.

(ODC1 Gene, NCI Thesaurus)

This allele, which encodes ornithine decarboxylase protein, is involved in the conversion of ornithine to putrescine in the first step of the polyamine biosynthesis pathway.

(ODC1 wt Allele, NCI Thesaurus)

An X-linked urea cycle metabolic disorder characterized by deficiency of ornithine carbamoyltransferase, resulting in the accumulation of amino acids and ammonia in the serum.

(Ornithine Carbamoyltransferase Deficiency Disease, NCI Thesaurus)

Polyamines are important for stabilizing DNA structure, for the DNA double strand-break repair pathway, and as antioxidants, and inhibition of ornithine decarboxylase inhibits cell growth.

(Ornithine Decarboxylase Inhibitor, NCI Thesaurus)

This species is nonmotile, non-spore forming, not acid fast, catalase, oxidase, phosphatase, urease, ornithine decarboxylase, and indole positive, reduces nitrate, not beta-hemolytic, produces a strong odor, but does not hydrolyze esculin.

(Pasteurella pneumotropica, NCI Thesaurus)

This species is nonmotile, non-spore forming, not acid fast, catalase, oxidase, phosphatase, and ornithine decarboxylase positive, urease negative, reduces nitrate, and does not hydrolyze esculin or grow on MacConkey's agar.

(Pasteurella canis, NCI Thesaurus)

This species is nonmotile, non-spore forming, not beta-hemolytic, oxidase, urease, ornithine decarboxylase, and indole negative, phosphatase positive, reduces nitrate, does not hydrolyze esculin or acidify galactose, and slowly and weakly ferments carbohydrates.

(Pasteurella bettyae, NCI Thesaurus)

An X-linked urea cycle metabolic disorder characterized by deficiency of ornithine transcarbamylase, resulting in the accumulation of ammonia in the serum.

(Ornithine Transcarbamylase Deficiency, NCI Thesaurus)

N(1),N(11)-bis(ethyl)norspermine (DENSPM), a N-terminally alkylated tetraamine and polyamine mimetics, disrupts polyamine pool homeostasis by modulating the activities of the biosynthetic enzymes, ornithine decarboxylase (ODC), and S-adenosylmethionine decarboxylase (AdoMetDC).

(Diethylnorspermine, NCI Thesaurus)

This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.

(Isotretinoin, NCI Thesaurus)