Orteronel

An orally bioavailable non-steroidal androgen synthesis inhibitor of steroid 17alpha-monooxygenase (17,20 lyase) with potential antiandrogen activity. TAK-700 binds to and inhibits the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells. The cytochrome P450 enzyme CYP17A1 (P450C17), localized to the endoplasmic reticulum (ER), exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces steroidal hormones, such as progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. (NCI Thesaurus)

YOU MAY ALSO LIKE

Ortataxel

A semisynthetic, second-generation taxane derivative with potential antineoplastic activity. Ortataxel binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of…

Orris Root Extract

The oil extracted from the roots of Iris germanica, Iris florentina, and Iris pallida. Orris root oil is used as a perfume…

Orphenadrine Citrate

The citrate salt form of orphenadrine with a muscle relaxant property. Although the mechanism of action has not been fully elucidated, orphenadrine…

Orphenadrine

A muscarinic antagonist with muscle relaxant activity. Although the mechanism of action has not been determined, orphenadrine appears to block muscarinic acetylcholine…

Orphan Nuclear Receptor Gene

Orphan Nuclear Receptor Genes (NR Superfamily) encode numerous Orphan Nuclear Receptor (NRs) transcription factors thought to be activated by as yet unknown…

Orphan drug designation

A status given to certain drugs called orphan drugs, which show promise in the treatment, prevention, or diagnosis of orphan diseases. An…