| Health / Medical Topics |
OSI-7904L
Definition 1
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called thymidylate synthase inhibitors. (NCI Dictionary)
Definition 2
A liposome-encapsulated formulation of the benzoquinazoline folate analog OSI-7904 with antineoplastic activity. As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication. Liposome encapsulation improves the efficacy and increases the half-life of OSI-7904. (NCI Thesaurus)
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