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OXIDATIVE PHOSPHORYLATION
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An enzymatic process in cell metabolism that synthesizes ATP from ADP
Classified under:
Nouns denoting natural processes
Hypernyms ("oxidative phosphorylation" is a kind of...):
biological process; organic process (a process occurring in living organisms)
Holonyms ("oxidative phosphorylation" is a part of...):
citric acid cycle; Krebs citric acid cycle; Krebs cycle; tricarboxylic acid cycle (in all plants and animals: a series of enzymatic reactions in mitochondria involving oxidative metabolism of acetyl compounds to produce high-energy phosphate compounds that are the source of cellular energy)
Context examples:
Cancer cells often generate energy through glycolytic fermentation more than oxidative phosphorylation, suggesting that manipulation of metabolism may provide a therapeutic strategy.
(Glycolysis Pathway, NCI Thesaurus/BIOCARTA)
Mitochondria are the principal energy source of the cell and contains the cytochrome enzymes of terminal electron transport and the enzymes of the citric acid cycle, fatty acid oxidation, and oxidative phosphorylation.
(Mitochondrion, NCI Thesaurus)
When oxygen is available, the pyruvate can be converted to acetyl-CoA and enter the Krebs Cycle, where the acetyl-CoA will be completely oxidized and generate ATP through oxidative phosphorylation.
(Glycolysis Pathway, NCI Thesaurus/BIOCARTA)
Oxidative phosphorylation does not work in the absence of oxygen, however, and in the absence of oxygen glycolysis is forced to a halt due to a lack of NAD+, unless NAD+ is regenerated through fermentation.
(Glycolysis Pathway, NCI Thesaurus/BIOCARTA)
