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OXIDOREDUCTASE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An enzyme that catalyzes oxidation-reduction
Classified under:
Hypernyms ("oxidoreductase" is a kind of...):
enzyme (any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions)
Hyponyms (each of the following is a kind of "oxidoreductase"):
oxygenase (an oxidoreductase that catalyzes the incorporation of molecular oxygen)
Context examples:
This allele, which encodes NADPH-dependent FMN-and FAD-containing oxidoreductase protein, is putatively involved in the metabolic activation of chemicals, such as anticancer drugs, via one-electron reduction.
(NDOR1 wt Allele, NCI Thesaurus)
The systematic name is based on donor: acceptor oxidoreductase.
(Oxidoreductase, NCI Thesaurus)
Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction, which is essential to anaerobic energy metabolism.
(Nitazoxanide, NCI Thesaurus)
Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1).
(Oltipraz, NCI Thesaurus)
AIF is both a mitochondrial intermembrane flavoprotein with oxidoreductase activity and a caspase-independent death effector that, similar to cytochrome c, is released from mitochondria early in the apoptotic process.
(Apoptosis Inducer BZL101, NCI Thesaurus)
This agent displays selectivity activity towards both hypoxic solid tumors, which exhibits higher expression of cytochrome P450 reductase, and well-oxygenated malignant cells that overexpress the bioreductive enzyme NQO1 (NAD(P)H: quinone oxidoreductase).
(Apaziquone, NCI Thesaurus)
When b-lap is activated by NAD(P)H:quinone oxidoreductase-1 (NQO1) this agent creates a futile oxidoreduction, generating highly reactive oxygen species (ROS) that results in DNA damage.
(Beta-lapachone Prodrug ARQ 761, NCI Thesaurus)
An oxidoreductase that catalyzes the conversion of Coenzyme A to oxalyl-Coenzyme A and the reduction of NADP+ to form NADPH through the cleavage of a glyoxylate molecule.
(Glyoxylate Dehydrogenase (Acylating), NCI Thesaurus)
The Ah receptor/ARNT heterodimer binds to dioxin-responsive elements and alters expression of a number of genes including; CYP1A1, CYP1A2, CYP1B1, and NAD(P)H quinone oxidoreductase.
(AHR Signal Transduction Pathway, NCI Thesaurus/BIOCARTA)
This induces the expression of a number of cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1 (TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the synthesis of the antioxidant glutathione (GSH).
(Nrf2 Activator RTA 408, NCI Thesaurus)
