| Health / Medical Topics |
p21 H-Ras Protein
p21 H-RAS protein is encoded by the H-RAS gene. RAS proteins are involved in transmembrane signal transduction as monomeric GTP-binding proteins, with intrinsic GTPase activity, that alternate between an inactive GDP-bound form and an active GTP-bound form. RAS proteins are activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein. Mitogen-stimulated RAS enhances MYC accumulation by stabilizing MYC protein. This stabilization is dependent on the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC. Mutations of specific amino acids activate c-RAS to transform cells and are implicated in a variety of human tumors. Allelic deletions of HRAS are correlated with progression and metastasis of carcinomas and sarcomas. (from OMIM 190020, SWISS-PROT P01112, and NCI) (NCI Thesaurus)
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