P2RY8/CRLF2 Fusion Gene

A fusion gene that results from an intrachromosomal deletion of the pseudoautosomal region 1of Xp22.3 and Yp11.3 which fuses the noncoding exon 1 of the P2RY8 gene to the entire coding region of the CRLF2 gene. This rearrangement is associated with Down syndrome-associated acute lymphoblastic leukemia. (NCI Thesaurus)

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P2RY8 wt Allele

Human P2RY8 wild-type allele is located in the vicinity of Xp22.33 and Yp11.3 and is approximately 75 kb in length. This allele,…

P2RY8 Gene

This gene plays a role in signaling.

P2RY2 wt Allele

Human P2RY2 wild-type allele is located within 11q13.5-q14.1 and is approximately 18 kb in length. This allele, which encodes P2Y purinoceptor 2,…

P2RY2 Gene

This gene plays a role in nucleotide receptor signaling.

p27 Regulation Pathway

p27/Kip1 regulates the cell cycle by inhibiting the checkpoint kinase cdk2/cyclin E and blocking cell cycle progression through the G1-S transition. …

p230 Fusion Protein Expression

Expression of a fusion protein with an apparent molecular weight of 230 kilodaltons that results from a fusion of the human genes…