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PALB2 wt Allele
Human PALB2 wt allele is located in the vicinity of 16p12.1 and is approximately 38 kb in length. This allele, which encodes partner and localizer of BRCA2 protein, may play roles in the repair of damaged DNA and DNA damage-induced checkpoints. Mutations in this gene are associated with about 3% of pancreatic carcinomas. (NCI Thesaurus)
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A molecular genetic abnormality that refers to a change in the nucleotide sequence of the PALB2 gene.
This gene may play a role in the repair of DNA damage that is resolved by recombination.
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