Palifosfamide Tromethamine

A synthetic mustard compound of the tromethamine (tris) salt of palifosfamide (Isophosphamide mustard), with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide irreversibly alkylates and crosslinks DNA through GC base pairs, resulting in irreparable 7-atom interstrand crosslinks. This leads to an inhibition of DNA replication and ultimately cell death. Unlike ifosfamide, this agent is not metabolized to acrolein or chloroacetaldehyde, metabolites associated with bladder and CNS toxicities. In addition, because palifosfamide does not require activation by aldehyde dehydrogenase, it may overcome the tumor resistance seen with ifosfamide. Stabilization with tris instead of lysine further increases stability and may further decrease nephrotoxicity. (NCI Thesaurus)

YOU MAY ALSO LIKE

Palifosfamide

A synthetic mustard compound with potential antineoplastic activity. An active metabolite of ifosfamide covalently linked to the amino acid lysine for stability,…

Palifermin

A form of keratinocyte growth factor (KGF) that is made in the laboratory. KGF stimulates the growth of cells that line the…

Palestinian Territory, Occupied

A collective name for the West Bank and the Gaza Strip, two territories in Palestine.

Palestinian

Denotes those persons of mainly Arabic speakers who regard themselves as a distinct branch of the Arabic-speaking peoples, with family origin in…

Paleozoic

An era of geological history which extends from the beginning of the Cambrian to the close of the Permian and is marked…

Paleoenvironmental proxy

An environmental remnant of the past (pollen grains, tree rings, lake sediments, pack rat middens, ice cores, coral skeletons) that assist researchers…