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Pancreatic Neuroendocrine Carcinoma
Definition 1
An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. The mitotic count is more than 20 per 10 HPF. According to the size of the malignant cells, the prominence of the nucleoli, and the amount of cytoplasm, it is classified either as small or large cell neuroendocrine carcinoma. (NCI Thesaurus)
Definition 2
A malignant endocrine neoplasm arising from islets of Langerhans of the pancreas. (NCI Thesaurus/CDISC)
Definition 3
Cancer arising from cells in the islets of Langerhans, which are found in the pancreas. (NCI Dictionary)
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