| Health / Medical Topics |
PARP 1/2 Inhibitor E7449
An orally available small molecule inhibitor of the nuclear enzymes poly (ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, E7449 selectively binds to PARP 1 and 2, thereby preventing the repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of single and double strand DNA breaks and promotes genomic instability eventually leading to apoptosis. PARP 1/2 inhibitor E7449 may enhance the cytotoxicity of DNA-damaging agents and of radiotherapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA. (NCI Thesaurus)
YOU MAY ALSO LIKE
A type of enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused…
An episodic form of ventricular tachycardia, with abrupt onset and termination.
An electrocardiographic finding of episodic tachycardia with abrupt onset and termination.
An electrocardiographic finding of episodic supraventricular tachycardia with abrupt onset and termination.
A rare disorder in which red blood cells are easily destroyed by certain immune system proteins. Symptoms include blood clots, and red…
An electrocardiographic finding of the sudden onset of transient AV block, which is often associated with preexisting conduction disorders.
