PAX3/FKHR Peptide Vaccine

A synthetic peptide vaccine based on the sequences of a translocation mutation of 2 transcriptional factor genes, PAX3 and FKHR. PAX3/FKHR fusion proteins are frequently found in patients with rhabdomyosarcomas. Vaccination with PAX3/FKHR peptide may stimulate the host immune response to elicit a cytotoxic T-cell response against tumor cells that express this PAX3/FKHR fusion protein. (NCI Thesaurus)

YOU MAY ALSO LIKE

PAX3/FKHR

An antisense oligonucleotide targeting mRNA of the chimeric PAX3/FKHR fusion gene, an oncogenic transcriptional activator found in rhabdomyosarcomas. PAX3/FKHR antisense oligonucleotide…

PAX3 wt Allele

Human PAX3 wild-type allele is located within 2q35-q37 and is approximately 99 kb in length. This allele, which encodes paired box gene…

PAX3 Gene

This gene plays a role in the transcriptional activation of target genes. It is involved in melanogenesis, neurogenesis and skeletal muscle…

PAX2 wt Allele

Human PAX2 wt allele is located in the vicinity of 10q24.31 and is approximately 84 kb in length. This allele, which encodes…

PAX2 Gene

This gene is involved in gene expression and cellular proliferation.

PAX1 wt Allele

Human PAX1 wild-type allele is located in the vicinity of 20p11.2 and is approximately 10 kb in length. This allele, which encodes…