PCNU

A chloroethylnitrosourea compound and an alkylating agent with antineoplastic property. PCNU inhibits DNA synthesis by alkylating DNA and causing DNA cross links, thereby inducing apoptosis. In addition, this agent may be associated with pulmonary, hepatic, and hematologic toxicities. Unlike other nitrosoureas, PCNU has strong alkylating while weak carbamoylating activity. (NCI Thesaurus)

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Primary CNS lymphoma. Cancer that forms in the lymph tissue of the brain, spinal cord, meninges (outer covering of the brain), or…

PCNA wt Allele

Human PCNA wild-type allele is located within 20pter-p12 and is approximately 30 kb in length. This allele, which encodes proliferating cell nuclear…

PCNA Gene

This gene plays a role in DNA metabolic processes, such as DNA repair and replication.

PCM1/RET Fusion Protein

A fusion protein encoded by the PCM1/RET fusion gene. This protein is comprised of approximately 1600 N-terminal amino acids from the pericentriolar…

PCM1/RET Fusion Gene

A fusion gene that results from a chromosomal translocation t(8;10)(p21.3;q11.2) which fuses the 5' portion of the PCM1 gene to the 3'…

PCM1 wt Allele

Human PCM1 wild-type allele is located within 8p22-p21.3 and is approximately 107 kb in length. This allele, which encodes pericentriolar material 1…