Health / Medical Topics |
PD0325901
An orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. MEK inhibitor PD325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. (NCI Thesaurus)
YOU MAY ALSO LIKE
A quinazolone compound with anti-tumor activity. PD-168393 is a cell-permeable, irreversible, and selective inhibitor of ligand-dependent epidermal growth factor (EGF) receptor…
A protein found on T cells (a type of immune cell) that helps keep the body’s immune responses in check. When PD-1…
Human PCYT1A wild-type allele is located in the vicinity of 3q29 and is approximately 74 kb in length. This allele, which encodes…
This gene is involved in phosphatidylcholine biosynthesis
A regimen consisting of procarbazine, lomustine (CCNU) and vincristine used for the treatment of low grade, adult oligodendroglial tumors.
An abbreviation for a chemotherapy combination used to treat certain types of brain tumors. It is often used with radiation therapy. It…