PDGFRB wt Allele

Human PDGFRB wild-type allele is located within 5q31-q32 and is approximately 42 kb in length. This allele, which encodes beta platelet-derived growth factor receptor protein, is involved in mitogenesis for cells of mesenchymal origin. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. (NCI Thesaurus)

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PDGFRB Gene Rearrangement

Rearrangement of the PDGFRB gene, resulting in the formation of a fusion transcript and aberrant tyrosine kinase activity. It has been described…

PDGFRB Gene

This gene plays a role in mitogenic activities affecting mesenchymal cells and a translocation in the gene results in chronic myelomonocytic…

PDGFRA wt Allele

Human PDGFRA wild-type allele is located within 4q11-q13 and is approximately 69 kb in length. This allele, which encodes alpha platelet-derived growth…

PDGFRA Protein Variant

A variation in the amino acid sequence for the platelet-derived growth factor receptor alpha protein.

PDGFRA Gene Rearrangement

Rearrangement of the PDGFRA gene, resulting in the formation of a fusion transcript and aberrant tyrosine kinase activity. It has been described…

PDGFRA Gene Mutation

A molecular genetic abnormality indicating the presence of a mutation in the PDGFRA (platelet-derived growth factor receptor, alpha polypeptide) gene on chromosome…