PEG Recombinant Human Megakaryocyte Growth and Development Factor

Definition 1

A pegylated formulation containing a recombinant growth factor with thrombopoietic activity. The recombinant human megakaryocyte growth and development factor (rHuMGDF) component of this formulation is a nonglycosylated, truncated form of the Mpl ligand. Mpl ligand, also known as thrombopoietin, stimulates the production of megakaryocyte precursor cells, megakaryocytes, and mature platelets. rHuMGDF is complexed with polyethylene glycol to prolong its half life in vivo and is used for the treatment and prevention of thrombocytopenia. (NCI Thesaurus)

Definition 2

A form of megakaryocyte growth and development factor (MGDF) that is made in the laboratory. MGDF comes from the protein thrombopoietin, which is normally made in the body to help make platelets. PEG-rhMGDF is being studied as a way to increase the number of platelets in patients receiving chemotherapy. (NCI Dictionary)

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