| Health / Medical Topics |
Pegaptanib Sodium
The sodium salt form of pegaptanib, a 28-mer RNA aptamer covalently linked to two branched 20-kD polyethylene glycol (PEG) chains, with anti-angiogenic activity. Pegaptanib binds and blocks the activity of the extracellular vascular endothelial growth factor, specifically the 165-amino acid isoform (VEGF165). This prevents VEGF165 from binding to VEGF receptors, thereby blocking angiogenesis as well as preventing VEGF165-induced increases in vessel permeability. VEGF165 is preferentially involved in pathological ocular neovascularisation. (NCI Thesaurus)
YOU MAY ALSO LIKE
A 28-mer RNA aptamer covalently linked to two branched 20-kD polyethylene glycol (PEG) chains, with anti-angiogenic activity. Pegaptanib binds and blocks the…
Human PEG3 wild-type allele is located in the vicinity of 19q13.4 and is approximately 31 kb in length. This allele, which encodes…
This gene is involved in both tumor suppression and apoptosis.
A form of megakaryocyte growth and development factor (MGDF) that is made in the laboratory. MGDF comes from the protein thrombopoietin, which…
A long-acting formulation of recombinant interferon alpha subtype 2b (IFN-a2b) protein, in which IFN-a2b is coupled, via proline, to polyethylene glycol (PEG),…
A form of megakaryocyte growth and development factor (MGDF) that is made in the laboratory. MGDF comes from the protein thrombopoietin, which…
