Health / Medical Topics |
Pegdinetanib
Definition 1
A pegylated form of a thermostable and protease resistant peptide targeting human vascular endothelial growth factor receptor-2 (VEGFR-2) with potential antiangiogenic activity. Derived from the 10th type III domain of human fibronectin and one of the natural ligands, pegdinetanib binds to VEGFR-2 and prevents activation of VEGFR-2 by other activating ligands. This may inhibit the growth of new tumor blood vessels. (NCI Thesaurus)
Definition 2
A substance being studied in the treatment of cancer. CT-322 may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor and a type of antiangiogenesis agent. (NCI Dictionary)
YOU MAY ALSO LIKE
A drug used to treat hepatitis C infections. It is also being studied in the treatment and prevention of cancer. It is…
A drug used to treat acute lymphoblastic leukemia (ALL). It is a form of the drug asparaginase that is linked to a…
The sodium salt form of pegaptanib, a 28-mer RNA aptamer covalently linked to two branched 20-kD polyethylene glycol (PEG) chains, with anti-angiogenic…
A 28-mer RNA aptamer covalently linked to two branched 20-kD polyethylene glycol (PEG) chains, with anti-angiogenic activity. Pegaptanib binds and blocks the…
Human PEG3 wild-type allele is located in the vicinity of 19q13.4 and is approximately 31 kb in length. This allele, which encodes…
This gene is involved in both tumor suppression and apoptosis.