| Health / Medical Topics |
Pelitrexol
Definition 1
A water soluble antifolate with anti-proliferative activity. Pelitrexol inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required for DNA replication and RNA transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately inhibits tumor cell proliferation (NCI Thesaurus)
Definition 2
A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called glycinamide ribonucleotide formyl transferase inhibitors. (NCI Dictionary)
YOU MAY ALSO LIKE
A substance being studied in the treatment of some types of cancer. It blocks the action of certain proteins that are part…
An autosomal dominant inherited condition caused by mutations in the lamin B receptor gene. It is characterized by defects in the neutrophil…
The determination of the amount of Pelger Huet anomaly present in a sample.
A regimen consisting of cisplatin, epirubicin, leucovorin and fluorouracil used for the treatment of advanced-stage gastric cancer. This regimen, developed in Europe,…
A substance that is being studied for the treatment of cancer.
The essential oil of Pelargonium roseum. Pelargonium roseum oil is used for its aromatic properties and as an ingredient in skincare…
