Health / Medical Topics

    Peplomycin

    Definition 1

    A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI Thesaurus)

    Definition 2

    An antineoplastic agent derived from BLEOMYCIN. (NLM, Medical Subject Headings)




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