| Health / Medical Topics |
Phaleria macrocarpa Extract DLBS-1425
An extract of the flesh from the fruit of Phaleria macrocarpa, an Indonesian herbal medicine, with potential antineoplastic activity. Although the active ingredients and exact components are unclear, gallic acid and its derivatives in DLBS-1425 appear to inhibit the phosphoinositide-3 kinase (PI3K)/protein kinase B (AKT) signaling pathway by reducing PI3K transcription followed by a reduction in AKT phosphorylation. This extract also appears to induce apoptosis through induction of pro-apoptotic genes such as BAX, BAD and PUMA and inhibition of the apoptosis suppressor Bcl-2. (NCI Thesaurus)
YOU MAY ALSO LIKE
A bone in the fingers or toes.
A hereditary syndrome affecting the central nervous system that is associated with lesions of the skin and retina. Representative examples include neurofibromatosis,…
A vesicle formed by the fusion of the plasma membrane around large particles during phagocytosis.
An organelle formed by the fusion of a phagosome with the lysosome, where the contents of the phagosome are degraded.
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling,…
Phagocytosis Inhibition involves interference with, or restraint of, the process of endocytosis of particulate material by phagocytes, such as microorganisms or cellular…
