Health / Medical Topics |
Phenprocoumon
An orally available, long-acting derivative of coumarin with anticoagulant activity. Upon administration, phenprocoumon inhibits the vitamin K epoxide reductase enzyme; inhibition of this enzyme prevents the formation of the reduced, active form of vitamin K (vitamin KH2), which is essential for the carboxylation of glutamate residues of vitamin K-dependent proteins. This prevents the activation of vitamin K-dependent coagulation factors II, VII, IX, and X and the anticoagulant proteins C and S, which abrogates both thrombin production and thrombus formation. (NCI Thesaurus)
YOU MAY ALSO LIKE
The hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the…
A synthetic, dibenzamine alpha adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth…
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called signal transduction…
The ability of an organism to adapt to a changing environment through the manipulation of its phenotype, without the alteration of its…
The assemblage of traits or outward appearance of an individual. It is the product of interactions between genes and between genes and…
The determination of the amount of phenothiazine present in a sample.