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Phenylephrine/Phenylpropanolamine/Guaifenesin
A combination preparation containing phenylephrine, phenylpropanolamine and guaifenesin with decongestant and expectorant activities. Phenylephrine and phenylpropanolamine, direct-acting sympathicomimetic amines, activate alpha-adrenergic receptors in the nasal mucosa thereby causing vasoconstriction, reduces swelling of nasal mucous membranes and decreasing nasal and sinus congestion. Phenylpropanolamine also releases norepinephrine from its storage sites resulting in the effects already described. Guaifenesin increases respiratory tract mucus secretions and reduces the viscosity of mucus secretion by reducing adhesiveness and surface tension as well as increasing hydration of mucus, thereby increasing the efficiency of removing accumulated secretions from the upper and lower airways and making cough more productive. (NCI Thesaurus)
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