Phosphatidylcholine Biosynthesis Pathway

The main components of biological membranes are phosphoglyceride lipids composed of a glycerol unit esterified to two fatty acids and a polar alcohol group. The properties of phospholipids give lipid bilayer membranes their self-organizing structure. The polar alcohol group is hydrophilic and organizes itself in the membrane facing outward toward water, while the hydrophobic fatty acid alkyl chains face inward toward other fatty acid chains. One of the primary membrane phospholipids is phosphatidylcholine, in which the polar head group is composed of phosphocholine. The biosynthesis of phosphatidylcholine and phosphatidylethanolamine follow similar routes. The first step in phosphatidylcholine is the phosphorylation of choline to make phosphocholine, which is then activated by CTP. CDP-choline reacts with diacylglycerol to produce phosphatidylcholine (NCI Thesaurus/BIOCARTA)

YOU MAY ALSO LIKE

Phosphatidylcholine Biosynthesis

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. Choline kinase is the initial enzyme that produces phosphocholine…

Phosphatidic Acid

A glycerol backbone covalently bound to a phosphate group in one position, and fatty acids in the 2nd and 3rd positions. Phosphatidic…

Phosphate to Creatinine Ratio Measurement

The determination of the ratio of phosphate compared to creatinine present in a sample. The measurement may be expressed as a ratio…

Phosphate Measurement

A quantitative measurement of the amount of phosphate present in a sample.

Phosphate Clearance Measurement

The determination of the amount of the phosphate clearance in a sample.

Phosphate Buffer

A chemical reagent containing at least any one of the many phosphoric acid derivatives, usually in salt form. The phosphoric salt…