| Health / Medical Topics |
Phosphatidylinositol
A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide. It is a very important minor phospholipid in eukaryotes, involved in signal transduction processes. Contains myo inositol linked through the 1 hydroxyl group to phosphatidic acid. The 4 phosphate (PIP) and 4, 5 bisphosphate derivatives PIP2) are formed and broken down in membranes by the action of specific kinases and phosphatases (futile cycles). Signal sensitive phospholipase C enzymes remove the inositol moiety, in particular from 1,4,5 trisphosphate (PIP2) as inositol 1,4,5 triphosphate (Ins P3: IP3). Both the diacyl glycerol and products act as second messengers. (NCI Thesaurus)
YOU MAY ALSO LIKE
Any substance that inhibits phosphatidylinositol 3-kinase (phosphatidylinositide 3-kinase), an enzyme that catalyzes the phosphorylation of the 3 position hydroxyl group of the…
Phosphatidylethanolamine N-methyltransferase (199 aa, ~22 kDa) is encoded by the human PEMT gene. This protein plays a role in the methylation of…
Dietary phospholipid containing ethanolamine.
Phosphatidylcholine:ceramide cholinephosphotransferase 2 (365 aa, ~42 kDa) is encoded by the human SGMS2 gene. This protein is involved in cell growth. …
Phosphatidylcholine:ceramide cholinephosphotransferase 1 (419 aa, ~49 kDa) is encoded by the human SGMS1 gene. This protein plays a role in apoptosis. …
An oral preparation of the flavonoid silybin with potential antioxidant and chemopreventive activities. Silybin, also known as silibinin, is a mixture of…
