Phosphoprotein Associated with GEMs

Encoded by human PAG Gene, ubiquitous 432-aa 47-kDa Phosphoprotein Associated with GEMs is a type III plasma transmembrane adaptor protein located predominantly in membrane rafts (GEMs), associated with FYN and CSK tyrosine kinase, and thought to be involved in T cell activation and immunoreceptor signal transduction. PAG contains a 16-aa extracellular domain, a transmembrane domain, a putative palmitoylation site, and a 397-aa cytoplasmic tail with 9 potential tyrosine phosphorylation sites, ITAM-like motifs, and multiple putative casein kinase II and protein kinase C phosphorylation sites. Two Pro-rich sequences may bind to SH3 domains. PAG recruits CSK to the plasma membrane, independent of FYN. After T-cell activation, association with CSK, but not FYN, decreases. PAG/CSK may increase the signaling threshold for initiating an immune response, keeping lymphocytes in a resting state. (NCI Thesaurus)

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