Health / Medical Topics

    Pibrozelesin Hydrobromide

    The hydrobromide salt form of pibrozelesin, a semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2, with antineoplastic activity. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis. (NCI Thesaurus)




    YOU MAY ALSO LIKE

    A semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine…
    A fluorescent dye of benzimidazole derivative. Pibenzimol binds to AT-specific sites in the minor groove of duplex DNA and inhibits topoisomerase…
    Human PIAS3 wild type allele is located in the vicinity of 1q21 and is approximately 11 kb in length. This allele, which…
    This gene is involved in transcriptional coregulation and protein degradation.
    Human PIAS1 wild-type allele is located in the vicinity of 15q23 and is approximately 137 kb in length. This allele, which encodes…
    This gene is involved in both signal transduction and the sumoylation of proteins.

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact