| Health / Medical Topics |
PICALM wt Allele
Human PICALM wild-type allele is located in the vicinity of 11q14 and is approximately 112 kb in length. This allele, which encodes phosphatidylinositol-binding clathrin assembly protein, is involved in the modulation of receptor mediated endocytosis. Genetic variation may be associated with Alzheimer's Disease. Diffuse histiocytic lymphomas are associated with a translocation, t(10;11)(p13;q14), involving this gene and the MLLT10 gene. (NCI Thesaurus)
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This gene plays a role in receptor mediated endocytosis.
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