Picropodophyllin

A cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells. (NCI Thesaurus)

YOU MAY ALSO LIKE

Picrasinoside H

A quassinoid glycoside phytochemical isolated from the plant Picrasma ailanthoides with potential antineoplastic activity.

Picosecond

A unit of time equal to one trillionth of a second.

Picornavirus

A family of non-enveloped, positive-stranded RNA viruses with an icosahedral capsid.

Picoplatin

A new generation organic platinum analog with an extended spectrum of antineoplastic activity. Designed to overcome platinum drug resistance, picoplatin alkylates DNA,…

Picomole per Liter per Microgram

Picomoles per liters per microgram.

Picomole per Liter

A unit of concentration (molarity unit) equal to one trillionth of a mole (10E-12 mole) per one liter of solution.