| Health / Medical Topics |
Pimonidazole
A 2-nitroimidazole with hypoxic selectivity and potential radiosensitizing activities. Pimonidazole is reduced in hypoxic environments such as those found in tumors. In hypoxic cells, reduced pimonidazole binds to thiol-containing proteins. The resulting complexes accumulate in hypoxic tumors, thereby depleting radioprotective thiol compounds and sensitizing tumor cells to be more susceptible for radiation treatment. (NCI Thesaurus)
YOU MAY ALSO LIKE
The essential oil extracted from the leaves of Pimenta dioica. Pimenta leaf oil is used to treat tooth and gum pain. …
A 33-epi-chloro-derivative of the ascomycin macrolactam with immunosuppressant property. Pimecrolimus binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the…
An orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity…
Human PIM2 wild-type allele is located in the vicinity of Xp11.23 and is approximately 6 kb in length. This allele, which encodes…
This gene plays a role in protein phosphorylation, cell proliferation and the regulation of apoptosis.
Human PIM1 wild-type allele is located in the vicinity of 6p21.2 and is approximately 5 kb in length. This allele, which encodes…
