Health / Medical Topics |
Pladienolide Derivative E7107
A synthetic urethane derivative of pladienolide D with potential antineoplastic activity. Pladienolide derivative E7107 is generated from the 12-membered macrolide pladienolide D, one of several macrolides derived from the bacterium Streptomyces platensis Mer-11107. This agent appears to bind to the 130-kDa subunit 3 (spliceosome-associated protein 130; SAP130) of the splicing factor 3b (SF3b), resulting in inhibition of pre-messenger RNA splicing and the arrest of cell-cycle progression. The splicing factor SF3b is a multiprotein complex integral to the accurate excision of introns from pre-messenger RNA; the subunit SAP130 associates with U2 snRNP and is recruited to prespliceosomal complexes. (NCI Thesaurus)
YOU MAY ALSO LIKE
The formation of the placenta in the uterus.
A rare gestational trophoblastic tumor characterized by the presence of a diffuse cellular infiltrate composed of intermediate trophoblasts and cytotrophoblasts and by…
Expressed in activated, but not resting, macrophages and in placenta, prostate, colon, and kidney by human PLAB Gene (BMP/TGF-Beta Family), 308-aa 34-kDa…
A non-neoplastic trophoblastic disorder characterized by the presence of remnants of intermediate trophoblasts in the uterine cavity from a previous pregnancy. …
The separation of the placenta from the uterine wall during labor; it begins at the placental center and leads to an expulsion…
A polyp in the uterine cavity that is formed by placenta remnants.