Library / English Dictionary

PLASMINOGEN ACTIVATOR

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

Protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysis

Synonyms:

plasminogen activator; urokinase

Classified under:

Nouns denoting substances

Hypernyms ("plasminogen activator" is a kind of...):

peptidase; protease; proteinase; proteolytic enzyme (any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis)

Credits

 Context examples: 

This allele, which encodes urokinase plasminogen activator surface receptor protein, plays a role in the regulation of both cell-surface plasminogen activation and localized degradation of the extracellular matrix.

(PLAUR wt Allele, NCI Thesaurus)

Agonists such as ADP, thrombin, epinephrine and collagen activate the release of APP and plasminogen activator inhibitor I (an important regulator of coagulation) from platelet storage granules.

(Platelet Amyloid Precursor Protein Pathway, NCI Thesaurus/BIOCARTA)

A member of the serpin family of serine protease inhibitor proteins that inhibits plasminogen activator type proteases.

(Plasminogen Activator Inhibitor, NCI Thesaurus)

Synthesized and secreted locally from vascular endothelial cells; primary physiologic inhibitor of tissue plasminogen activator; also inhibits urokinase; implicated in thrombotic and hemorrhagic disorders.

(Plasminogen Activator Inhibitor, NIH CRISP Thesaurus)

Desmopressin binds to V2 receptors in renal collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption.

(Desmopressin, NCI Thesaurus)

Also called Activase, r-tPA, and recombinant tissue plasminogen activator.

(Alteplase, NCI Dictionary)

Also called urokinase plasminogen activator (uPA)-derived peptide A6.

(A6, NCI Dictionary)

Aminocaproic acid competitively reduces the conversion of plasminogen to plasmin by plasminogen activators.

(Aminocaproic Acid, NCI Thesaurus)

A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme.

(Alteplase, NCI Thesaurus)

Proteolytic removal of PPBP residues 1-9 produces active peptide CTAP-III/LA-PF4, which stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan, as well as formation and secretion of plasminogen activator.

(Beta-Thromboglobulin, NCI Thesaurus)