| Health / Medical Topics |
Platelet Amyloid Precursor Protein Pathway
The amyloid-beta peptide (Ab), a proteolytic fragment of amyloid precursor protein (APP), is the major component of senile plaques, the hallmark of Alzheimer's disease. Platelets contain both APP and Ab and probably contribute greater than 90% of circulating APP. The soluble APP is the major inhibitor of coagulation factors IXa and XIa, and platelet aggregation. Agonists such as ADP, thrombin, epinephrine and collagen activate the release of APP and plasminogen activator inhibitor I (an important regulator of coagulation) from platelet storage granules. These important molecules released from platelets are key regulators of hemostasis, the physiologic arrest of hemorrhage at site of vascular leakage. (NCI Thesaurus/BIOCARTA)
YOU MAY ALSO LIKE
Any cell adhesion process that involves the association of platelets via adhesion molecules.
Eph kinases are a family of receptor tyrosine kinases with an extracellular domain that binds their ligand, the ephrins, and an intracellular…
The determination of the amount of the association of platelets to one another via adhesion molecules in a biological sample.
The determination of the amount or magnitude of the platelet aggregation present in a sample.
Platelet Activation involves initiation of a set of stimulated platelet activities involved in aggregation of platelets and fibrin during blood coagulation. …
Platelet Activating Factor Stabilization inhibits conjugation, transport, oxidation, or proteolysis of a phospholipid derivative (platelet activating factor) formed by platelets, basophils, neutrophils,…
