| Health / Medical Topics |
Plinabulin
An orally active diketopiperazine derivative with potential antineoplastic activity. Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, thereby interrupting equilibrium of microtubule dynamics. This disrupts mitotic spindle assembly leading to cell cycle arrest at M phase and blockage of cell division. In addition, plinabulin may also inhibit growth of proliferating vascular endothelial cells, thereby disrupting the function of tumor vasculature that further contributes to a decrease in tumor cell proliferation. (NCI Thesaurus)
YOU MAY ALSO LIKE
A drug used to treat some types of testicular cancer. It is also used to treat a higher-than-normal amounts of calcium in…
Human PLG wild-type allele is located in the vicinity of 6q26 is approximately 50 kb in length. This allele, which encodes plasminogen…
This gene is involved in blood coagulation/hemostasis. It also plays a role in embryonic development, tissue remodeling and inflammation.
A disorder affecting a network of nerves, blood vessels, or lymph vessels.
Plexin domain-containing protein 1 (500 aa, ~56 kDa) is encoded by the human PLXDC1 gene. This protein is involved in endothelial tube…
A schwannoma characterized by a plexiform or multinodular growth pattern. It usually arises from the skin or subcutaneous tissues in the…
