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POTENTIATION
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
(medicine) the synergistic effect of two drugs given simultaneously
Classified under:
Nouns denoting natural processes
Hypernyms ("potentiation" is a kind of...):
synergism; synergy (the working together of two things (muscles or drugs for example) to produce an effect greater than the sum of their individual effects)
Domain category:
medical specialty; medicine (the branches of medical science that deal with nonsurgical techniques)
Derivation:
potentiate (increase the effect of or act synergistically with (a drug or a physiological or biochemical phenomenon))
Context examples:
Pentobarbital sodium binds to the gamma-aminobutyric acid (GABA)-A subtype receptor, resulting in modulation of chloride transport through receptor channels and potentiation of GABA-induced increases in chloride conductance.
(Pentobarbital Sodium, NCI Thesaurus)
Clorazepate dipotassium exerts its effect by de-activating the nervous system through potentiation of the inhibitory effect of gamma-aminobutyric acid (GABA) on the GABA-A receptors by binding to a site that is distinct from the GABA binding site.
(Clorazepate Dipotassium, NCI Thesaurus)
Based on sensitization theory, co-administration of trastuzumab (anti-HER-2/neu monoclonal antibody) and HER-2/neu intracellular domain protein may result in the potentiation of a HER2/neu-specific cytotoxic T lymphocyte (CTL) response against tumor cells overexpressing the HER2/neu protein.
(HER-2/neu Intracellular Domain Protein, NCI Thesaurus)
Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses.
(Phenytoin, NCI Thesaurus)
A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII) . Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors.
(Long-Term Potentiation Pathway, NCI Thesaurus/KEGG)
