PPARG wt Allele

Human PPARG wild-type allele is located in the vicinity of 3p25 and is approximately 146 kb in length. This allele, which encodes peroxisome proliferator-activated receptor gamma protein, plays a role in adipocyte differentiation. The gene has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Mutations in the gene can lead to type 2 insulin-resistant diabetes, hypertension, obesity, colon cancer, familial partial lipodystrophy type 3 and carotid intimal medial thickness 1. (NCI Thesaurus)

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PPARG Gene

This gene plays a regulatory role in adipocyte differentiation.

PPARD wt Allele

Human PPARD wild-type allele is located in the vicinity of 6p21.2 and is approximately 85 kb in length. This allele, which encodes…

PPARD Gene

This gene is involved in signaling and transcriptional regulation.

PPARA wt Allele

Human PPARA wild-type allele is located within 22q12-q13.1 and is approximately 93 kb in length. This allele, which encodes peroxisome proliferator-activated receptor…

PPARA Gene

This gene is involved in ligand-mediated transcriptional regulation.

PPAR-alpha Gene Regulation Pathway

The most recognized mechanism by which peroxisome proliferators regulate gene expression is through a PPAR/RXR heterodimeric complex binding to a peroxisome proliferator-response…