| Health / Medical Topics |
Pradefovir Mesylate
The mesylate salt form of pradefovir, a cyclodiester antiviral prodrug with specific activity against hepatitis B virus (HBV). Pradefovir is specifically metabolized in the liver by hepatic enzymes, mainly by CYP4503A4, to adefovir. In turn, adefovir is phosphorylated by cellular kinases to its activated form adevofir diphosphate. By competing with the natural substrate dATP, the diphosphate form is incorporated into viral DNA and inhibits RNA-dependent DNA polymerase. This causes DNA chain termination and eventually results in an inhibition of HBV replication. (NCI Thesaurus)
YOU MAY ALSO LIKE
A cyclodiester antiviral prodrug with specific activity against hepatitis B virus (HBV). Pradefovir is specifically metabolized in the liver by hepatic enzymes,…
An infrastructure to conduct office-based research that will answer the questions facing general dental practitioners in the routine care of their…
A person professionally engaged medical practice who is appointed to a post or duties.
A person who works in a specific profession. For example, a doctor or nurse is a healthcare practitioner.
A group of practicing clinicians who link their expertise and resources in collaborative efforts to address important research questions of shared…
A network of dental practices that will establish the infrastructure to perform a wide variety of oral health research studies in Idaho,…
