Predicted Steady State Volume of Distribution

Definition 1

An estimate of the volume of distribution at steady state, which is the mean residence time (MRT) extrapolated to infinity times steady state clearance (MRTINF*Clss), based on the predicted last concentration. (NCI Thesaurus)

Definition 2

The volume of distribution at steady state based on the predicted CLST for a substance administered by intravascular dosing. (NCI Thesaurus/CDISC)

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Predicted Area Under the Urinary Excretion Rate Curve Infinity

The area under the urinary excretion rate curve (AURC) extrapolated to infinity, based on the last predicted excretion rate.

Predicted Area Under the First Moment Curve Percent Extrapolation

The percent of the predicted area under the first moment curve (AUMC) that is extrapolated to infinity.

Predicted Area Under the First Moment Curve Infinity

The area under the first moment curve (AUMC) extrapolated to infinity, based on the last predicted concentration.

Predicted Area Under the Curve Percent Extrapolation

The percentage of the area under the curve (AUC) extrapolated to infinity from Tlast based on the predicted value for concentration at…