Prednisolone 21-Phosphate

The phosphate ester form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. As a glucocorticoid receptor agonist, prednisolone 21-phosphate binds to specific intracellular glucocorticoid receptors, and causes the ligand-receptor complex to be translocated to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. (NCI Thesaurus)

YOU MAY ALSO LIKE

Prednisolone

A drug that lessens inflammation and suppresses the body’s immune response. It may also kill cancer cells. Prednisolone is used to…

Prednimustine

The prednisolone ester of chlorambucil and nitrogen mustard alkylating agent with antineoplastic activity. Prednimustine itself is not cytotoxic, however, it becomes cytotoxic…

Prednicarbate

A synthetic non-halogenated double-ester derivative of the corticosteroid prednisolone with anti-inflammatory, antipruritic and vasoconstrictive properties. Following skin permeation, prednicarbate enters cells and…

Predictor

Information or variable that supports a probabilistic estimate of future events.

Predictive Value

An expression of the likelihood that a given test result correlates with the presence or absence of disease.

Predictive factor

A condition or finding that can be used to help predict whether a person’s cancer will respond to a specific treatment. …