PRIMA-1 Analog APR-246

A methylated derivative and structural analog of PRIMA-1 (p53 re-activation and induction of massive apoptosis), with potential antineoplastic activity. Upon administration, PRIMA-1 analog APR-246 covalently modifies the core domain of mutated forms of cellular tumor antigen p53 (p53) through the alkylation of thiol groups. These modifications restore both the wild-type conformation and function to mutant p53, which reconstitutes endogenous p53 activity, leading to cell cycle arrest and apoptosis in tumor cells. This agent may work synergistically with other antineoplastic agents. p53, a tumor suppressor and transcription factor normally activated upon DNA damage, is frequently mutated and overexpressed in cancer cells; it plays a key role in both DNA repair and the induction of apoptosis. (NCI Thesaurus)

YOU MAY ALSO LIKE

PRIM2B Gene

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus. Two of the enzymes that…

PRIM2 wt Allele

Human PRIM2 wild-type allele is located within 6p12-p11.1 and is approximately 331 kb in length. This allele, which encodes DNA primase large…

PRIM2 Gene

This gene is involved in discontinuous DNA replication.

PRIM1 wt Allele

Human PRIM1 wild-type allele is located within 12q13 and is approximately 21 kb in length. This allele, which encodes DNA primase small…

PRIM1 Gene

This gene plays a role in discontinuous DNA replication.

Prilocaine Hydrochloride

The hydrochloride salt form of prilocaine, an intermediate-acting local anesthetic of the amide type chemically related to lidocaine. Prilocaine hydrochloride binds to…