Primaquine

A synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA. This agent eliminates tissue (exo-erythrocytic) malarial infection, preventing the development of the erythrocytic forms of the parasite which are responsible for relapses in Plasmodium vivax and ovale malaria. Primaquine is active against late hepatic stages (hypnozoites, schizonts). (NCI Thesaurus)

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PRIMA-1 Analog APR-246

A methylated derivative and structural analog of PRIMA-1 (p53 re-activation and induction of massive apoptosis), with potential antineoplastic activity. Upon administration, PRIMA-1…

PRIM2B Gene

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus. Two of the enzymes that…

PRIM2 wt Allele

Human PRIM2 wild-type allele is located within 6p12-p11.1 and is approximately 331 kb in length. This allele, which encodes DNA primase large…

PRIM2 Gene

This gene is involved in discontinuous DNA replication.

PRIM1 wt Allele

Human PRIM1 wild-type allele is located within 12q13 and is approximately 21 kb in length. This allele, which encodes DNA primase small…

PRIM1 Gene

This gene plays a role in discontinuous DNA replication.