Progenipoietin

A recombinant, chimeric, dual-receptor agonist fusion protein with immunohematopoietic activity. Progenipoietin (ProGP) consists of portions of the ligands for granulocyte colony-stimulating factor (G-CSF) and human fetal liver tyrosine kinase-3 (FLT3); variants progenipoietin-1, 2 and 3 differ in the orientation of the two receptor agonists. ProGP binds simultaneously to G-CSF and FLT3 receptors with receptor affinities approximately two- to three-fold higher than the respective native ligands. When administered in vivo, this agent may augment the number of circulating granulocytes and dendritic cells (DCs). ProGP may promote the proliferation of and prevent apoptosis in several human hematopoietic cell lineages, exhibiting the additive activities of a combination of C-GSF and FLT3. (NCI Thesaurus)

YOU MAY ALSO LIKE

Profile

An analysis (often in graphical form) representing the extent to which something exhibits various characteristics.

Proficiency Testing Challenge

Any individual test given to a laboratory as part of a proficiency test.

Proficiency Testing

A program for the determination of laboratory performance where individual labs perform the same test on the same or similar items or…

Professor

A courtesy title for a teacher of the highest academic rank in a college or university.

Professional Practice

Health care professional business directed towards treatment and care of patients.

Professional Organization or Group

A formal group of people that exists to further a particular profession.