| Health / Medical Topics |
Prolactin 16-kD Fragment
A 16 kD N-terminal fragment of prolactin formed endogenously by cleavage of intact prolactin. Possessing anti-angiogenic properties, prolactin 16-kD fragment inhibits the pro-angiogenic effects of basal fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) on endothelial cell proliferation, migration, and capillary organization. This agent also induces caspase-mediated endothelial cell apoptosis and upregulates the expression of plasminogen activator inhibitor-1 (PAI-1); PAI-1 inhibits the activity of urokinase, an enzyme essential to angiogenesis. (NCI Thesaurus)
YOU MAY ALSO LIKE
A hormone that is made by the pituitary gland (a pea-sized organ in the center of the brain). Prolactin causes a woman’s…
A structure or space in a prokaryotic cell.
Organisms without a cell nucleus or any other membrane-bound organelles. Most prokaryotes are bacteria but the group includes both the Bacteria and…
Detector data acquired in a specified direction from the subject. It represents a view from a certain direction.
A prediction made by extrapolating from past observations.
Calculated, estimated, or predicted based on present data or trends.
